- Record: found
- Abstract: found
- Article: found
Directions and Essential Experimental Findings of Statin Treatment in Diabetic Patients
Author Summary
Summary
The purpose of conducted study was to determine which of the different types of statins ensure a better control of biological markers in diabetic patients and which of the lipid molecules studied, could be a first choice of lipid-lowering therapy in people suffering from diabetes. The measurement of blood glucose levels depending on type of statin used, was another target of this research. Dyslipidemia was a major risk factor for cardiovascular complications in people with diabetes. According to ROC statistical analysis it was found that Atorvastatin was the most effective statin in controlling dyslipidemia in diabetic patients, because has ensured optimum control of HDL, LDL - cholesterol, triglycerides and glycemic values, effect which was resulted from the particular chemical structure of Atorvastatin. Atorvastatin was discovered to be the best predictor in diabetes mellitus type 2 treatment, with a sensitivity about 78% and specificity to 45%., the most highest values compared to Rosuvastatin and Simvastatin. Area Under the Curve (AUC = 0.610; AUC ˃ 0.600)
In the diabetic patients treated with Atorvastatin, blood glucose level was the lowest of the three statins: 95.88 mg/dL; p = 0.034 and presented the highest statistically significant value (p ˂ 0.05), The lowest triglycerides value was measured in diabetic patients treated with Atorvastatin (110.97 mg/dL, p = 0.042), very high statistically significant.
Between three studied antidiabetic drugs: Atorvastatin, Rosuvastatin and Simvastatin., it was discovered that Atorvastatin was the best and the most effective predictor in diabetes mellitus type 2 patients treatment. Atorvastatin was provided with a sensitivity about 78% and specificity to 45%., which were the most highest values compared to those of patients treated with Rosuvastatin and Simvastatin. Area Under the Curve assigned to patients treated with Atorvastatin (AUC = 0.610; AUC ˃ 0.600) . Other two statins (Rosuvastatin and Simvastatin) do not appear to be positive predictors in diabetes mellitus type 2 therapy and healing (AUC assigned to Rosuvastatin = 0.529 and AUC for Simvastatin = 0,439; AUC ˂ 0.600).
Abstract
The purpose of conducted study was to determine which of the different types of statins ensure a better control of biological markers in diabetic patients and which of the lipid molecules studied, could be a first choice of lipid-lowering therapy in people suffering from diabetes. The measurement of blood glucose levels depending on type of statin used, was another target of this research. Dyslipidemia was a major risk factor for cardiovascular complications in people with diabetes. According to ROC statistical analysis it was found that Atorvastatin was the most effective statin in controlling dyslipidemia in diabetic patients, because has ensured optimum control of HDL, LDL - cholesterol, triglycerides and glycemic values, effect which was resulted from the particular chemical structure of Atorvastatin. Atorvastatin was discovered to be the best predictor in diabetes mellitus type 2 treatment, with a sensitivity about 78% and specificity to 45%., the most highest values compared to Rosuvastatin and Simvastatin. Area Under the Curve (AUC = 0.610; AUC ˃ 0.600)
Content
Author and article information
References
Pelin Ana Maria, Gavat Cristian Catalin, Balan Gabriela, Popescu Eugenia, Georgescu Costinela Valerica. Particularities of Statin Therapy in Diabetic Patients. Revista de Chimie. Vol. 68(4):720–725. 2017. Revista de Chimie SRL. [Cross Ref]