This paper examines the critical role of specimen quality in percutaneous image-guidedbiopsies, particularly focusing on the minimization of crush artifact, fragmentation, andcellular disruption. Traditional side notch biopsy devices and their association with crushartifact are evaluated, addressing how this impacts cancer typing accuracy. Furthermore, thepotential superiority of full core biopsy devices, exemplified by the Argon Medical Biopicedevice, is discussed in the context of providing higher-quality specimens with reduced tissuedistortion. The objective is to delineate the implications of biopsy technique and deviceselection on diagnostic accuracy and patient outcomes in oncology.